6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CAS: 1181816-12-5
Molecular Formula: C11H17NO3
6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester - Names and Identifiers
6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C11H17NO3 |
| Molar Mass | 211.25758 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| Melting Point | 114.5-116 °C |
| Boling Point | 314.7±42.0 °C(Predicted) |
| pKa | -0.93±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD15071430 |
6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester - Introduction
6-oxo-2-azaspiro [3.3] heptane-2-carboxylic acid tert-butyl ester, chemical formula C12H19NO4, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless or light yellow liquid
-Molecular weight: 237.29g/mol
-Boiling Point: 135-140°C(0.1 mmHg)
-Density: 1.10g/cm³
-Solubility: Soluble in organic solvents such as alcohols, ethers, ketones and chlorinated hydrocarbons
Use:
-tert-Butyl esters are often used as solvents and intermediates
-Used in organic synthesis to prepare heterocyclic compounds and other organic chemical reactions
Preparation Method:
6-Oxo-2-azaspiro [3.3] heptane-2-carboxylic acid tert-butyl ester can be prepared by the following steps:
1. Benzaldehyde reacts with tert-butyl alcohol to generate the corresponding aldehyde and ketone compounds.
2. Aldehydes and ketones react with spironolactone to produce spironolactone under acid catalysis.
3. the reaction of spironolactone with sodium nitrite to generate sub-nitride spironolactone.
4. finally, the sub-nitride spironolactone is reacted with formic anhydride to obtain tert-butyl 6-oxo-2-azaspiro [3.3] heptane -2-carboxylate.
Safety Information:
-The compound is irritating and corrosive, so personal protective equipment such as appropriate protective gloves, goggles and laboratory coats should be worn during operation.
-Avoid contact with skin, eyes and clothing. If you accidentally touch the skin, rinse immediately with plenty of water. If you accidentally touch the eyes, rinse immediately with plenty of water and seek medical attention.
-A well-ventilated laboratory environment should be maintained during use.
Nature:
-Appearance: colorless or light yellow liquid
-Molecular weight: 237.29g/mol
-Boiling Point: 135-140°C(0.1 mmHg)
-Density: 1.10g/cm³
-Solubility: Soluble in organic solvents such as alcohols, ethers, ketones and chlorinated hydrocarbons
Use:
-tert-Butyl esters are often used as solvents and intermediates
-Used in organic synthesis to prepare heterocyclic compounds and other organic chemical reactions
Preparation Method:
6-Oxo-2-azaspiro [3.3] heptane-2-carboxylic acid tert-butyl ester can be prepared by the following steps:
1. Benzaldehyde reacts with tert-butyl alcohol to generate the corresponding aldehyde and ketone compounds.
2. Aldehydes and ketones react with spironolactone to produce spironolactone under acid catalysis.
3. the reaction of spironolactone with sodium nitrite to generate sub-nitride spironolactone.
4. finally, the sub-nitride spironolactone is reacted with formic anhydride to obtain tert-butyl 6-oxo-2-azaspiro [3.3] heptane -2-carboxylate.
Safety Information:
-The compound is irritating and corrosive, so personal protective equipment such as appropriate protective gloves, goggles and laboratory coats should be worn during operation.
-Avoid contact with skin, eyes and clothing. If you accidentally touch the skin, rinse immediately with plenty of water. If you accidentally touch the eyes, rinse immediately with plenty of water and seek medical attention.
-A well-ventilated laboratory environment should be maintained during use.
Last Update：2024-04-10 22:29:15
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Product Name: tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Visit Supplier Webpage Request for quotation
CAS: 1181816-12-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1181816-12-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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